Quick Answer
Guildrun Poison Conduit is a rare Poison relic whose official Demo 0.5.5 quest requirement fell from 200 to 150. The lower requirement makes a Poison route easier to complete, but the relic is still a commitment: the team must apply Poison consistently and survive long enough to reach its payoff. Exact reward text and current trigger details are To be confirmed outside the live game tooltip.
Take Poison Conduit when the current board already produces Poison and the next rewards can support that plan. Do not pick it only because a hero has a Poison keyword; the run needs enough application, time, and protection.
The Confirmed Change
The official patch confirms one exact update: the quest requirement changed from 200 to 150. That is a meaningful reduction, but it does not tell us how many fights, casts, or attacks the average run needs. Those outcomes vary with the board and are not official fixed values.
This page treats the change as versioned evidence. Older articles may still mention 200, while current Demo 0.5.6 pages should reference the 150 requirement inherited from 0.5.5 unless a later patch changes it.
Poison and Pollen
Pollen's Fae's Kiss is a useful related page because Demo 0.5.6 improved Sanctuary of Bloom's Poison scaling with Mana Regen. That does not make Poison Conduit a mandatory pairing, but it shows why a Poison relic and a Poison specialization can share a contextual link. Zuri's broader Poison and Stone Skin route is another possible comparison.
Read the Pollen Fae's Kiss guide and Guildrun Zuri guide for hero decisions. Use Guildrun relics for the general rule: choose a relic that strengthens what the current board already does.
Building the Quest
Quest relics are strongest when the condition is naturally produced by the board. If the team must spend every shop choice forcing Poison, the lower requirement may not compensate for the lost immediate power. If enemies live long enough for repeated Poison application and the team has a stable frontline, Conduit becomes easier to justify.
The exact trigger source, reward, and status stacking rules are To be confirmed in the official public pages. Do not publish an invented Poison total or a guaranteed completion floor. Show the patch requirement and explain the decision process instead.
Timing and Mode
In early progression, a 150 requirement may be reachable while the run is still learning the core loop, but only if Poison is already present. In Red Rift, a delayed quest must be balanced against immediate boss pressure. In Endless, the longer run gives more time for a status relic to mature, but the value of other damage and survival options also grows.
The official sources do not publish a current cross-mode tier ranking for Poison Conduit. Any mode recommendation is editorial and must stay patch-scoped. The current patch notes should be checked before using this page in a new strategy article.
Common Mistakes
The biggest mistake is confusing the quest requirement with the final reward. The second is choosing Poison Conduit without a reliable Poison source. The third is forcing status investment when the current fight requires immediate Defense or damage.
Avoid static “best relic” language. The official developer has repeatedly adjusted event and relic choices to make decisions less automatic. A current board-based answer is more durable than a universal tier label.
Current Verdict
Guildrun Poison Conduit is the current lower-requirement Poison quest relic, with the official threshold reduced from 200 to 150 in Demo 0.5.5. It fits a board that already applies Poison and can survive the quest window; exact reward text, completion timing, and universal rankings remain To be confirmed.